The use of appropriate models can minimize the number of drug candidates that later fail in human trials by accurately predicting the efficacy and the toxicity of each compound. This can be improved with more informed selection of the appropriate models. This book provides disorder-specific guidelines to selecting the appropriate non-human models for trials in the drug discovery and development process. Neurological Diseases is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for neurological disorders such as Alzheimer's, Parkinson's Disease and Huntington's Disease. This is the second volume in the three-volume set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, and is also available for purchase individually. This title includes case studies of real-life trials that resulted in moving to the human trials phases. It contains details for each disorder on how to analyze and determine what the results mean to the overall drug discovery/development process. Each chapter focuses on the translational issues surrounding each reward deficit disorder with connections between the use of animal models and human clinical trials.
- Limba : Engleza
- Data Publicarii : 18 Nov 2008
- Format : Hardback
- Numar pagini : 416
- ISBN : 9780123738554