Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds

J. Thomas August , M.W. Anders , Ferid Murad , Wolfgang Dekant

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental. Conjugation reactions have long been associated with the detoxification of xenobiotics. Recent studies suggest that Phase II reactions are an important mechanism for the bioactivation of xenobiotics. This special volume of Advances in Pharmacology features a two-color dust jacket. It summarizes the most recent information on: xenobiotic conjugation; drug toxicity, hypersensitivity, and targeting; chemical carcinogenesis; glutathione-, sulfate conjugate-, and glucuranide conjugate-dependent toxicity; and, bioactivation and bioconversion.
  • Limba : Engleza
  • Cuprins : J.A. Miller and Y.-J. Surh, Historical Perspectives on Conjugation-Dependent Bioactivation of Foreign Compounds. Glutathione-Dependent Toxicity: C. Andersson, E. Mosialou, R. Weinander, and R. Morgenstern, Enzymology of Microsomal Glutathione S-Transferase. B. Ketterer and L.G. Christodoulides, Enzymology of Cytosolic Glutathione S-Transferases. A.J.L. Cooper, Enzymology of Cysteine S-Conjugate b-Lyases. W. Dekant, S. Vamvakas,and M.W. Anders, Formation and Fate of Nephrotoxic and Cytotoxic Glutathione S-Conjugates: Cysteine Conjugate b-Lyase Pathway. T.A. Baille and K. Kassahun, Reversibility in Glutathione-Conjugate Formation. T.J. Monks and S.S. Lau, Glutathione Conjugation as a Mechanism for the Transport of Reactive Metabolites. F.P. Guengerich, Metabolism and Genotoxicity of Dihaloalkanes. R. Munday, Bioactivation of Thiols by One-Electron Oxidation. N. Ballatori, Glutathione Mercaptides as Transport Forms of Metals. Sulfate Conjugate-Dependent Toxicity: C.N. Falany and T.W. Wilborn, Biochemistry of Cyt
  • Data Publicarii : 06 Jul 1994
  • Format : Hardback
  • Numar pagini : 519
  • ISBN : 9780120329274
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