Handbook of Proteolytic Enzymes

Neil D. Rawlings , Alan John Barrett , J. Fred Woessner

Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigated in pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more. This is the only comprehensive book on proteolytic enzymes. It includes 671 chapters, each written by experts in their field, on proteolytic enzymes from all groups of living organisms and the viruses, including those that are currently major targets of pharmaceutical research. Accompanying CD-ROM provides fully searchable text, 2D structures of peptidases in color and links directly to PubMed and MEROPS databases. Each chapter describes in detail the enzyme name, its history, activity and specificity, structural chemistry, preparation, biological aspects and distinguishing features. Over 1000 peptidases are included in it.
  • Limba : Engleza
  • Cuprins : Sample of chapters listed according to catalytic type (chapter order will be reorganized by time of publication): Aspartic Peptidases: Introduction: aspartic peptidases and their clans; Rous sarcoma virus retropepsin and avian myeloblastosis virus retropepsin; Pepsin F Cysteine Peptidases: Introduction: the clans and families of cysteine peptidases; Coronavirus picornain-like cysteine proteinase; Calicivirus endopeptidases Metallopeptidases: Introduction: metallopeptidases and their clans; Ophiolysin; Philodryas venom metalloproteinases Serine Peptidases: Introduction: unsequenced serine peptidases; Muramoyl-pentapeptide carboxypeptidase; Tail-specific protease Threonine Peptidases: Introduction: clan PB containing N-terminal nucleophile peptidases; HslVU protease; Glycosylasparaginase and other self-processing N-terminal nucleophile amidohydrolases Unclassified Peptidases: Introduction: peptidases of unknown catalytic type; Murein tetrapeptide LD-carboxypeptidases; Tubulinyl-Tyr carboxypeptidase
  • Data Publicarii : 27 May 2004
  • Editie : 2 Rev ed
  • Format : Hardback
  • Numar pagini : 2368
  • ISBN : 9780120796106
2290.99 Lei
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