Progress in Medicinal Chemistry: v.42

George Lawton , D.K. Luscombe , A.W. Oxford , F. D. King , Gwynn P. Ellis

This volume includes information on recent advances in five important areas: an account of inhibitors of the caspase family of proteolytic enzymes that represent a new class of anti-inflammatory and antiapoptotic agents of potential value in rheumatoid arthritis; and a survey of semi-synthetic and totally synthetic antibiotics and anti-HIV agents and their sites of interaction; the development of inhibitors of the intracellular enzyme acyl-CoA: cholesterol O-acyltransferase (ACAT) for the treatment of hypercholesterolemia; a description of recent progress in growth hormone secretagogues, with the focus on strategies to improve oral bioavailability and duration of action; and information on inhibition of the proteolytic enzyme, hepatitis C protease N-3(NS3), (required for vital replication) as one of the most attractive targets for HCV infections.
  • Limba : Engleza
  • Data Publicarii : 15 Apr 2004
  • Format : Hardback
  • Numar pagini : 450
  • ISBN : 9780444511430
1087.99 Lei
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